Systemic Signaling
Systemic Signaling - Related Videos
10:36
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Cited by 5 •
2016
Integration of data from genome-wide sequencing experiments and metabolomics experiments is a challenge. In this paper we report, for the first time, generation, analysis and integration of transcriptome, cistrome and metabolome data from breast cancer cells treated with estradiol.
13:19
The Use of Chemostats in Microbial Systems Biology
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Cited by 67 •
2013
Cell growth rate is a regulated process and a primary determinant of cell physiology. Continuous culturing using chemostats enables extrinsic control of cell growth rate by nutrient limitation facilitating the study of molecular networks that control cell growth and how those networks evolve to optimize cell growth.
06:50
Wide-Field, Real-Time Imaging of Local and Systemic Wound Signals in Arabidopsis
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Cited by 7 •
2021
Extracellular glutamate-triggered systemic calcium signaling is critical for the induction of plant defense responses to mechanical wounding and herbivore attack in plants. This article describes a method to visualize the spatial and temporal dynamics of both these factors using Arabidopsis thaliana plants expressing calcium- and glutamate-sensitive fluorescent biosensors.
01:18
Second Order systems II
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2024
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero. If ζ...
01:21
First Order Systems
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2024
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior. When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
FAQs
These signal types provide different forms of biological information that can move from an initiating region to distant tissues. Their long-distance transmission may occur through vascular tissues, body fluids, or neural pathways. Comparing these signal classes helps researchers examine how organisms coordinate distant responses using chemical, electrical, or RNA-based information.
Transport routes determine how information reaches tissues away from the original stimulus. Vascular tissues, body fluids, and neural pathways each provide a means for signals to travel through the organism. Examining the route helps connect a local condition with the distant organs that ultimately change their activity, supporting analysis of whole-organism coordination.
Distant tissues may respond when signals bind receptors or alter cellular activity in target organs. This interaction links signal arrival with biological changes in the receiving tissue rather than treating transport as the final outcome. Studying these target responses helps explain how long-distance communication regulates growth, development, metabolism, immunity, and stress responses.
A stimulus that begins in one region can produce effects in tissues located elsewhere, allowing local conditions to influence coordinated biological activity. This connection integrates information across the organism instead of restricting the response to the initial site. In biology, it provides a framework for studying how organisms translate local changes into broader physiological or behavioral outcomes.
Research can focus on how long-distance communication contributes to growth, development, metabolism, immunity, and responses to environmental stress. These processes represent distinct outcomes that may depend on information reaching distant tissues and changing their activity. Examining them helps reveal how organisms coordinate multiple functions in response to internal or external conditions.
Systemic signaling is relevant to plant resilience because communication between tissues can connect environmental conditions with responses in distant parts of the organism. It also supports investigation of disease mechanisms by showing how altered communication may affect multiple tissues. In therapeutic research, these signaling relationships can identify strategies that target communication between organs or tissues.