Lower Body Negative Pressure Chamber
Lower Body Negative Pressure Chamber - Related Videos
11:26
Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
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Cited by 7 •
2014
Cerebral perfusion is maintained across a range of pressures via cerebral autoregulation. However, characterizing autoregulation requires prominent pressure fluctuations at regulated frequencies. The described protocol will show how oscillatory lower body negative pressure can generate pressure fluctuations to provide data for projection pursuit regression for quantification of the autoregulatory curve.
14:09
Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
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Cited by 31 •
2013
We describe a "gold standard" for evaluating orthostatic tolerance (OT) using tilt testing with combined lower body negative pressure (LBNP). This can be combined with non-invasive evaluations of cardiovascular reflex control. Normal and abnormal responses are defined.
07:26
Synthesis and Microdiffraction at Extreme Pressures and Temperatures
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Cited by 5 •
2013
The laser heated diamond anvil cell combined with synchrotron micro-diffraction techniques allows researchers to explore the nature and properties of new phases of matter at extreme pressure and temperature (PT) conditions. Heterogeneous samples can be characterized in situ under high pressure by 2D mapping and combined powder, single-crystal and multigrain diffraction approaches.
09:10
The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation
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Cited by 6 •
2019
Here, based on a clinician’s point-of-view, we propose a two-model lower body positive pressure (LBPP) protocol (walking and squatting models) in addition to a clinical, functional assessment methodology, including details for further encouragement of the development of non-drug surgical intervention strategies in knee osteoarthritis patients. However, we only present the effect of LBPP training in improvement of pain and knee function in one patient through three-dimensional gait analysis. The...
10:11
Whole-Body Nanoparticle Aerosol Inhalation Exposures
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Cited by 51 •
2013
A whole-body nanoparticle aerosol inhalation exposure facility was constructed for nano-sized titanium dioxide (TiO2) inhalation toxicology studies. This system provides nano-TiO2 aerosol test atmospheres that have: 1) a steady mass concentration; 2) a homogenous composition free of contaminants; and 3) a stable particle size distribution during aerosol generation.
FAQs
The pressure change creates a controlled shift in blood distribution rather than requiring the participant to stand. As air pressure around the legs and pelvis falls below atmospheric pressure, blood is drawn toward the lower extremities. This reduces the amount of blood returning to the heart, allowing investigators to examine the cardiovascular consequences of reduced venous return under standardized conditions.
Reduced venous return can challenge the maintenance of both blood pressure and cardiac output. The resulting cardiovascular strain makes compensatory regulation observable, including the role of autonomic control in responding to altered circulation. This is important because the chamber provides a controlled orthostatic stress model for studying responses that may otherwise arise during standing or other conditions.
Instead of relying only on a naturally occurring change in posture, the method deliberately alters pressure around the lower body. That design focuses the experiment on blood redistribution toward the legs and pelvis and the resulting reduction in venous return. Researchers can therefore investigate cardiovascular tolerance under a repeatable, controlled challenge relevant to standing-related stress.
Because the intervention changes where blood is distributed, it can be used to study more than heart performance alone. Investigators can examine vascular function, fluid shifts, and autonomic regulation as linked parts of the response. Considering these outcomes together helps reveal whether cardiovascular adaptation preserves circulation when blood is displaced toward the lower body.
An experimental session begins by positioning the participant so the lower body can be enclosed and sealed at the waist. Air pressure around the legs and pelvis is then reduced below atmospheric pressure. Investigators use this controlled challenge to observe cardiovascular responses as venous return falls, rather than relying only on uncontrolled changes in posture or environment.
Responses can show how well an individual maintains blood pressure and cardiac output during reduced venous return. The same challenge can reveal changes related to autonomic regulation, vascular function, and fluid distribution. Together, these observations provide a functional picture of cardiovascular tolerance, rather than a measurement of only one isolated component.
Microgravity can be studied through its relevance to altered cardiovascular blood distribution and adaptation. The chamber provides a controlled stress model for examining tolerance and evaluating related countermeasures. In this context, researchers can investigate how effectively cardiovascular regulation responds when blood is shifted toward the lower extremities, supporting studies of adaptation to unusual physical conditions.