Male-specific Y Region

The male-specific Y region is the portion of the Y chromosome found only in typical male genomes, making it an important subject in genetics, inheritance, and human population biology. Most of this region does not recombine with the X chromosome during meiosis, so it is transmitted largely from father to son and preserves linked genetic variation across generations. It contains genes involved in sex determination and male development, including the SRY region, as well as repeated DNA sequences that can vary among individuals. Researchers analyze these patterns in studies of ancestry, population history, genetic diversity, and Y-chromosome-related disorders.

Male-specific Y Region - Related Videos

Research

JoVE Journal - Biology
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Isolation of Specific Genomic Regions and Identification of Associated Molecules by enChIP

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2016

The identification of molecules associated with specific genomic regions of interest is required to understand the mechanisms of regulation of the functions of these regions. This protocol describes procedures to perform engineered DNA-binding molecule-mediated chromatin imunoprecipitation (enChIP) for identification of proteins and RNAs associated with a specific genomic region.

Research

JoVE EoE - Caenorhabditis elegans (worm)

Enriching for Males: Maintaining a Stock of Male C. elegans

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2023

Nematodes can be propagated easily in the lab--in part because hermaphrodites can reproduce by self-fertilization. However, genetic crosses and other experiments may require a large number of males. This video describes a method to enrich for male C. elegans.

Evaluation of Ribbon Synapses at Specific Frequency Regions of Mouse Cochlea

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2025

This video demonstrates a method for evaluating ribbon synapses in specific regions of the mouse cochlea. It utilizes immunostaining and confocal imaging techniques to identify functional synapses across different frequency regions in each cochlear turn.

Education

JoVE Science Education - Clinical Skills

Male Rectal Exam

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2023

Source: Joseph Donroe, MD, Internal Medicine and Pediatrics, Yale School of Medicine, New Haven, CT While its usefulness in cancer screening is debated, the male rectal examination remains an important part of the physical exam. The exam is indicated in selected patients with lower urinary tract symptoms, urinary and/or fecal incontinence or retention, back pain, anorectal symptoms, abdominal complaints, trauma patients, unexplained anemia, weight loss, or bone pain. There are no absolute...

Dissection and Isolation of Region-Specific Decellularized Lung Tissue

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2023

Presented here is a protocol for the isolation of regional decellularized lung tissue. This protocol provides a powerful tool for studying complexities in the extracellular matrix and cell-matrix interactions.

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