Radial Notch
Radial Notch - Related Videos
04:57
An Antibody Uptake Assay for Imaging Notch/DeltaD Signaling in Zebrafish Radial Glia Progenitors
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2025
This video demonstrates an antibody uptake assay to image Notch/DeltaD signaling in zebrafish radial glia progenitors. It involves mounting agarose-embedded dechorionated zebrafish embryos, injecting a dye solution targeting DeltaD ligands on RGPs, and imaging under a fluorescence microscope for asymmetric cell division confirming Notch/DeltaD signaling activation.
09:06
Antibody Uptake Assay for Tracking Notch/Delta Endocytosis During the Asymmetric Division of Zebrafish Radial Glia Progenitors
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Cited by 5 •
2023
This work develops an antibody uptake assay for imaging intra-lineage Notch/DeltaD signaling in dividing radial glia progenitors of the embryonic zebrafish brain.
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Cited by 13 •
2017
Notch signaling is a form of cellular communication that relies upon direct contact between cells. To properly induce Notch signaling in vitro, Notch ligands must be presented to cells in an immobilized state. This protocol describes methods for in vitro stimulation of Notch signaling in mouse osteoclast precursors.
01:23
Radial System Protection
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2024
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system. In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
03:14
Notch Signaling Pathway
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2021
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule. The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
FAQs
Its curved surface provides a stable contact for the radial head while the radius turns during pronation and supination. The annular ligament strengthens this relationship by holding the radial head against the ulna without preventing rotation. This combination allows the proximal radioulnar joint to guide forearm movement while limiting unwanted displacement of the radial head.
The annular ligament acts as a retaining structure around the radial head at the radial notch. By keeping the radial head closely aligned with the ulna, it preserves joint stability during forearm motion. At the same time, its arrangement permits the radial head to rotate, so restraint and mobility can occur together at the proximal radioulnar joint.
During pronation and supination, the radial head rotates while remaining supported at the proximal radioulnar joint. The radial notch supplies the matching concave surface, and the annular ligament maintains contact with the ulna. Their coordinated function helps transfer the radius through its rotational path without losing the alignment needed for controlled forearm movement.
Stability depends on the relationship between the notch, the radial head, and the surrounding annular ligament rather than on the notch alone. The notch provides a shaped bony surface, while the ligament reinforces the connection and holds the radial head in position. Together, these structures support smooth rotation and reduce the likelihood of radial-head displacement during movement.
In physical examination, the radial notch is relevant when assessing the proximal radioulnar joint and the coordination of forearm pronation and supination. Clinicians can relate restricted or abnormal movement to the alignment of the radial head with the ulna. This anatomical reference also helps organize findings when examining suspected proximal forearm or elbow-region injuries.
The radial notch provides an important anatomical reference for assessing injuries involving the radial head, proximal ulna, or their joint relationship. Radial head dislocation and proximal forearm fractures may disrupt normal alignment or movement at this region. Understanding the notch and its ligamentous support helps clinicians interpret how such injuries could affect stability and forearm rotation.