Hepatic Artery Ligation
Hepatic Artery Ligation - Related Videos
04:46
Targeting Liver Tumors with Oncolytic Viruses via the Hepatic Artery
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2025
The video demonstrates locoregional delivery of oncolytic viruses through hepatic arterial injection as a therapeutic approach for hepatocellular carcinoma. These viruses selectively replicate in tumor cells, inducing cell lysis and releasing tumor cell-associated antigens. This process triggers immunogenic cell death, inducing an anti-tumor response.
05:47
Modified Technique for Coronary Artery Ligation in Mice
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Cited by 8 •
2013
The surgical procedure used to induce experimental myocardial infarction in mice begins with left thoracotomy between the third and the fourth ribs in order to visualize the anterior surface of the heart and left lung. The left coronary artery is ligated, the chest is closed and the mouse is allowed to recover spontaneously.
18:47
Surgical Procedures for a Rat Model of Partial Orthotopic Liver Transplantation with Hepatic Arterial Reconstruction
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Cited by 22 •
2013
Orthotopic liver transplantation in rats is an indispensable experimental model for biomedical research. Here we present our surgical procedures for orthotopic rat liver transplantation with hepatic arterial reconstruction using a 50% partial graft.
16:19
Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
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Cited by 5 •
2014
Auxiliary liver transplantation provides a temporary support in acute hepatic failure, until regeneration of the failing liver. The heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) renders sufficient liver function. We developed an analogous technique in the rat, to examine the influence of the portal vein arterialization on the morphology and function of the graft.
07:41
Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
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Cited by 47 •
2011
Numerous genetic manipulations and/or intramyocardial injections of genes, proteins, cells, and/or biomaterials are superimposed upon the dimension of time in studies of acute ischemia/ reperfusion injury and chronic remodeling in mice. This video illustrates the microsurgical procedures for ischemia/reperfusion, permanent coronary artery ligation, and intramyocardial injection studies.
FAQs
Normal liver tissue receives blood from both the hepatic artery and the portal vein, so reducing arterial flow does not remove its entire blood supply. Many liver tumors depend more heavily on arterial circulation. This difference creates a selective experimental pressure: tumor tissue may experience greater ischemic stress than surrounding liver, allowing researchers to examine vascular dependence.
By lowering oxygenated blood flow to the liver, hepatic artery ligation creates a model of tumor ischemia, meaning inadequate blood supply to tumor tissue. Researchers can then examine how hepatic tumors respond when perfusion is restricted. These observations help investigate mechanisms governing tumor growth, survival, and sensitivity to treatments that depend on vascular conditions.
Vascular dependence describes the extent to which a tumor relies on a particular blood supply to maintain growth. Hepatic artery ligation tests that dependence by reducing arterial perfusion while portal venous supply remains available to normal liver tissue. Differences in tumor response can therefore provide evidence about how strongly tumor growth is linked to arterial circulation.
The procedure may be performed surgically or used as an experimental intervention to occlude the hepatic artery. Its central experimental feature is controlled interruption of arterial flow, followed by evaluation of the resulting tumor and liver responses. The overview does not specify a single operative technique, so the exact workflow depends on the research design.
Researchers may use it when they need to examine tumor ischemia, arterial vascular dependence, or responses to reduced blood flow. It is particularly relevant for experiments focused on how hepatic tumors grow under altered perfusion. The approach can also support studies of treatment sensitivity by showing how vascular restriction changes the tumor environment.
Hepatic artery ligation provides a way to investigate how changing blood flow within the liver influences regional treatment strategies. By reducing arterial perfusion, researchers can study interactions between vascular access, tumor blood supply, and therapeutic response. These experiments may clarify why altered circulation affects treatment sensitivity in hepatic tumors and surrounding liver tissue.