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Developmental Biology

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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
 

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Article doi: 10.3791/55520
April 7th, 2017

Summary April 7th, 2017

We present here a cell culture method for inducing mesenchymal-epithelial transitions (MET) in sarcoma cells based on combined ectopic expression of microRNA-200 family members and grainyhead-like 2 (GRHL2). This method is suitable for better understanding the biological impact of phenotypic plasticity on cancer aggressiveness and treatments.

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