Anti-cancer Treatments
Anti-cancer Treatments - Related Videos
07:29
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Cited by 27 •
2015
Pancreatic cancer stem cells (CSCs) can be expanded in vitro using the anchorage-independent sphere culture technique, which represents a powerful tool to study CSC biology and can serve as the first step to develop novel CSC-targeting therapies. Here the methodology for expanding, analyzing and targeting of pancreatic CSCs is provided.
15:17
Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
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Cited by 19 •
2011
We described a procedure for the disaggregation of colorectal cancer (CRC) to produce viable single cells, which are then captured on customized antibody microarrays recognizing surface antigens (DotScan CRC microarray). Sub-populations of cells bound to the microarray can be profiled by fluorescence multiplexing using monoclonal antibodies tagged with fluorescent dyes.
02:56
Treatment Resistent Cancers
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2023
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56
Treatment Resistant Cancers
0 Views •
2021
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
13:21
Antibody Generation: Producing Monoclonal Antibodies Using Hybridomas
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2023
Source: Frances V. Sjaastad1,2, Whitney Swanson2,3, and Thomas S. Griffith1,2,3,4 1 Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN 55455 2 Center for Immunology, University of Minnesota, Minneapolis, MN 55455 3 Department of Urology, University of Minnesota, Minneapolis, MN 55455 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455 Polyclonal antibodies are defined as a collection of antibodies directed against...
FAQs
Checkpoint inhibitors block inhibitory signals that normally restrain T cells. Removing this restraint can allow these immune cells to recognize and attack cancer cells more effectively. This mechanism makes checkpoint inhibition distinct from treatments that directly damage DNA or physically remove tumors, and it highlights how immune regulation influences therapeutic responses.
Chemotherapy and radiation act through DNA damage, whereas surgery removes the tumor directly. These approaches therefore target malignancy through different routes and may provide complementary effects when selected for the same disease. Comparing their mechanisms helps researchers and clinicians consider how tumor control can be balanced against potential damage to healthy tissue.
Immune surveillance helps explain how the immune system detects abnormal cells, while antigen recognition determines how immune cells identify tumor-associated targets. Inflammation can also shape tumor progression. Studying these processes connects cancer biology with immunology and infection research, where investigators examine how immune activation may support tumor control or influence disease behavior.
Treatment selection depends on tumor biology, disease stage, and patient factors. These variables help determine whether an approach centered on DNA damage, tumor removal, immune activation, or targeted therapy is appropriate. Considering them together supports treatment plans that address the specific cancer while seeking to limit unnecessary injury to healthy tissue.
Antibody therapies and cellular immunotherapies provide targeted options within anti-cancer treatment research. Their relevance comes from using immune-related mechanisms rather than relying only on broadly damaging approaches. In immunology and infection studies, these strategies help investigators examine how immune cells or antibody-based targeting can be directed toward malignant cells.
Research aims to achieve durable responses, meaning cancer control that persists over time, while reducing toxicity and limiting harm to healthy tissue. Investigators therefore assess more than immediate tumor reduction: they also consider how treatment mechanisms, immune activity, tumor characteristics, and patient factors relate to lasting benefit and tolerability.