Cerebral Oxygen Metabolism
Cerebral Oxygen Metabolism - Related Videos
11:39
Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
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Cited by 49 •
2013
We combined frequency-domain near-infrared spectroscopy measures of cerebral hemoglobin oxygenation with diffuse correlation spectroscopy measures of cerebral blood flow index to estimate an index of oxygen metabolism. We tested the utility of this measure as a bedside screening tool to evaluate the health and development of the newborn brain.
08:58
Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence
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Cited by 28 •
2011
We present an experimental procedure for measuring the partial pressure of oxygen (pO2) in cerebral vasculature based on oxygen-dependent quenching of phosphorescence. Animal preparation and imaging procedures were outlined for both large field of view CCD-based imaging of pO2 in rats and 2-photon excitation based imaging of pO2 in mice.
09:08
Detecting Reactive Oxygen Species
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2023
Reactive oxygen species are chemically active, oxygen-derived molecules capable of oxidizing other molecules. Because of their reactive nature, there are many deleterious effects associated with unchecked ROS production, including structural damage to DNA and other biological molecules. However, ROS can also be mediators of physiological signaling. There is accumulating evidence that ROS play significant roles in everything from activation of transcription factors to the mediation of...
05:41
Metabolic Profile Analysis of Zebrafish Embryos
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Cited by 42 •
2013
Zebrafish represent a powerful vertebrate model that has been under-utilised for metabolic studies. Here we describe a rapid way to measure the in vivo metabolic profile of developing zebrafish that allows the comparison of different mitochondrial function parameters between genetically or pharmacologically manipulated embryos, thereby increasing the applicability of this organism.
10:19
An Introduction to Cell Metabolism
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2023
In cells, critical molecules are either built by joining together individual units like amino acids or nucleotides, or broken down into smaller components. Respectively, the reactions responsible for this are referred to as anabolic and catabolic. These reactions require or produce energy typically in the form of a “high-energy” molecule called ATP. Together, these processes make up “Cell Metabolism,” and are hallmarks of healthy, living cells.JoVE’s introduction to cell metabolism briefly...
FAQs
Neuronal signaling and synaptic activity require a continuous energy supply. Cerebral oxygen metabolism supports this demand by providing oxygen for mitochondrial oxidative phosphorylation, the process that converts metabolic substrates into adenosine triphosphate, or ATP. ATP supplies usable cellular energy, while the same metabolic activity produces carbon dioxide and water. This links oxygen use directly to ongoing brain function.
Cerebral blood flow delivers oxygen to brain tissue, while oxygen consumption indicates how much of that supply supports cellular activity. Examining both measurements helps reveal whether tissue is receiving and using oxygen appropriately. This relationship can therefore support assessment of brain function, identification of impaired perfusion, and interpretation of changes in cerebral physiology.
Mitochondria provide the site where oxygen supports oxidative phosphorylation. In this process, metabolic substrates are converted into ATP, the energy source needed for neuronal signaling, synaptic activity, and cellular maintenance. Carbon dioxide and water are generated as products. Because these functions depend on sustained cellular energy production, mitochondrial oxygen use is central to the brain’s metabolic demands.
When cerebral perfusion is impaired, the delivery of oxygen to neural tissue may no longer match the requirements of active brain cells. Measuring oxygen consumption together with blood flow helps investigators and clinicians examine this imbalance rather than relying on either variable alone. The resulting information can contribute to evaluating brain function and studying disorders associated with impaired perfusion.
Assessment focuses on oxygen consumption and its relationship to cerebral blood flow. These measurements can be incorporated into neuroimaging or intensive care monitoring to characterize cerebral physiology. The resulting data help clinicians and researchers evaluate brain function, identify impaired perfusion, and follow physiological changes relevant to neurological disease or treatments that alter cerebral function.
Its measurement is particularly relevant when clinicians or researchers need to evaluate cerebral perfusion and energy use in conditions such as stroke, traumatic brain injury, and neurodegeneration. It also supports intensive care monitoring and neuroimaging. In these settings, oxygen-related measurements provide information about brain physiology that can aid disease investigation and treatment evaluation.
Neuroimaging applications can use oxygen-consumption and blood-flow measurements to investigate how brain tissue is functioning. These data help relate cerebral physiology to neuronal and synaptic activity, while also supporting assessment of perfusion. In research and clinical contexts, the measurements can contribute to studying neurological disorders and evaluating treatments that affect cerebral physiology.
Measurements of cerebral oxygen consumption and blood flow provide physiological outcomes for examining treatment effects. Changes in these variables can be assessed alongside brain function and perfusion, helping researchers or clinicians determine whether cerebral physiology has changed during treatment. This approach is relevant to neuroimaging, intensive care monitoring, and studies of disorders involving altered brain metabolism.