Personalized Aortic Repair
Personalized Aortic Repair - Related Videos
08:51
A New Murine Model of Endovascular Aortic Aneurysm Repair
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Cited by 3 •
2013
Histological and biochemical modifications after aneurysm endograft exclusion are still unclear. We describe a new model of endograft implantation on a murine aneurysm. Through thrombus analysis with and without persistant circulating blood stream interface, and new endovascular biomaterials evaluation, this model will help to better understand endovascular aneurysm exclusion pathobiology.
12:17
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Cited by 4 •
2017
Full-root aortic valve replacement by stentless aortic xenograft is a viable option in patients with small aortic roots. We describe, a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses, and discuss its limitations and alternative options.
09:12
Aortic Ring Assay
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Cited by 42 •
2009
Angiogenesis, the sprouting of blood vessels from pre-existing vasculature, is associated with both natural and pathological processes. Here we demonstrate an aortic ring assay that allows angiogenic potentiators and inhibitors to be directly added to aortic rings in culture. Sprouting and neovessel outgrowth can be determined by inspecting the aortic rings over a period of 6-12 days.
04:59
Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases
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Cited by 3 •
2025
This paper presents a protocol for the precise ultrasound-guided delivery of vascular stem cells to the aortic vessel wall. The technique effectively targets the vessel wall and promotes vascular repair in aortic aneurysms and dissections.
02:25
Overview of DNA Repair
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2020
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage. Chemically...
FAQs
High-resolution imaging provides the anatomical detail needed to evaluate the aorta and its surrounding branch vessels. Three-dimensional assessment then helps clinicians understand the spatial relationships relevant to treatment, while computational planning translates those findings into decisions about device selection, design, and placement. This workflow is especially valuable when complex anatomy makes standard visual assessment insufficient.
A successful repair must create a secure seal around the diseased aortic segment without obstructing essential branch arteries. Planning therefore balances two competing requirements: excluding or stabilizing the abnormal area and maintaining blood flow through important branches. The patient’s anatomy determines where a device or surgical technique can be positioned to meet both objectives.
Standard devices may not fit reliably when a patient has unusual vessel dimensions, a complex disease pattern, or a difficult aortic region. Personalized treatment uses anatomical assessment and computational planning to guide selection or design of a more suitable stent-graft or operative approach. The intended benefit is greater procedural precision and access to options that standard devices may not provide.
Treatment planning considers the patient’s anatomy, the pattern of aortic disease, and the broader clinical needs of the case. These factors influence whether clinicians select an endovascular stent-graft, use a surgical technique, or consider a device designed for the individual anatomy. Such decisions support a more patient-specific strategy rather than relying on a single standard configuration.
Planning begins with high-resolution imaging, followed by three-dimensional evaluation of the aorta and relevant branch vessels. Computational planning uses this anatomical information to guide device selection or design and determine an appropriate placement strategy. The resulting plan is intended to establish secure sealing while preserving essential arteries during treatment of an aneurysm, dissection, or another structural disorder.
The approach may involve selecting or designing an endovascular stent-graft, or choosing a surgical technique suited to the patient’s anatomy and disease pattern. Device placement is guided by the three-dimensional anatomical assessment and computational plan. This flexibility allows treatment planning to address complex aortic regions where a single device type or operative method may be inadequate.
Personalized aortic repair is particularly relevant for aneurysms, dissections, and other structural disorders involving complex aortic regions. It can expand treatment options when standard devices do not fit reliably and may improve procedural precision or reduce complications. More broadly, the approach reflects contemporary vascular and cardiovascular medicine’s emphasis on anatomy-guided, patient-specific decision-making.