Cervical Sympathetic Ganglion Block
Cervical Sympathetic Ganglion Block - Related Videos
11:49
Protocol for Culturing Sympathetic Neurons from Rat Superior Cervical Ganglia (SCG)
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Cited by 40 •
2009
This is a protocol describing how to isolate and culture primary sympathetic neurons from superior cervical ganglia (SCG) of newborn rat pups.
02:55
Effects of Ethanol-Induced Sympathetic Ganglion Block on Nerve Regeneration in a Canine Model
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2025
Source: Shionoya, Y., et al. Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve. J. Vis. Exp. (2018)This video demonstrates a canine model for inferior alveolar nerve (IAN) regeneration using a biodegradable scaffold and ethanol-induced sympathetic blockade. The procedure involves surgically accessing the cervical sympathetic ganglion and injecting ethanol to induce vasodilation. The resulting...
09:52
Inducing Dendritic Growth in Cultured Sympathetic Neurons
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Cited by 10 •
2012
We describe a protocol for using bone morphogenetic protein-7 (BMP-7) or Matrigel to selectively induce dendritic growth in primary sympathetic neurons dissociated from the superior cervical ganglia (SCG) of perinatal rats.
06:48
Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve
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Cited by 3 •
2018
We evaluated the effect of cervical sympathetic ganglion block on nerve repair using artificial nerve conduits. Male beagle dogs were each implanted with an artificial nerve across a 10-mm gap in the left inferior alveolar nerve; left cervical sympathetic ganglion was blocked by injecting 99.5% ethanol via lateral thoracotomy.
07:00
Generating Postganglionic Sympathetic Neurons from Human Pluripotent Stem Cells
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2025
This video demonstrates an in vitro method to generate postganglionic sympathetic neurons from human pluripotent stem cells (hPSCs). hPSCs are differentiated into neural crest cells (NCCs) on a basement membrane matrix support using a differentiation medium. The NCCs are then dissociated and formed into spheroids using another differentiation medium. Finally, the spheroids are transformed into postganglionic sympathetic neurons using a sympathetic neuron medium.
FAQs
The local anesthetic prevents action-potential transmission through postganglionic sympathetic fibers near the targeted cervical ganglia. Because sympathetic output is temporarily reduced rather than permanently eliminated, the block can reveal short-term changes in autonomic activity. This interruption provides a way to examine how sympathetic signaling contributes to regional physiological responses and pain.
The stellate ganglion is one of the cervical sympathetic ganglia that may be targeted during the block. Interrupting activity near this structure can reduce sympathetic influence in relevant regions and produce observable changes in blood flow, sweating, and pain signaling. These responses help connect a localized intervention with broader autonomic and sensory effects.
A temporary reduction in sympathetic activity can be examined alongside changes in pain signaling. If pain changes during the period of sympathetic interruption, the response may help investigators assess whether sympathetic activity contributes to the sensory experience. This makes the block useful for studying functional interactions between autonomic output and sensory nervous system processing.
A clinician deposits a local anesthetic near cervical sympathetic ganglia, including the stellate ganglion when it is selected as the target. The anesthetic temporarily interrupts transmission through postganglionic sympathetic fibers. Clinicians can then assess associated changes in regional blood flow, sweating, and pain signaling while the sympathetic activity is reduced.
The procedure may be considered when clinicians need to evaluate or manage sympathetically maintained pain. The overview identifies complex regional pain syndrome and selected head, neck, or upper-limb disorders as relevant contexts. Its temporary effect can provide information about sympathetic involvement while also potentially supporting pain management in appropriate cases.
Assessment can focus on regional blood flow, sweating, and pain signaling after sympathetic activity has been temporarily interrupted. These outcomes provide observable indicators of autonomic change and may help relate those changes to pain. In neuroscience research, comparing these responses supports investigation of how autonomic function interacts with sensory processing.