Orofacial Skin Stretch

Orofacial skin stretch is a mechanical deformation of facial or oral skin that activates sensory pathways involved in touch, movement, and perception. Stretching the skin stimulates mechanoreceptors, which convert tissue deformation into neural signals carried primarily by trigeminal afferents to brainstem and higher sensory circuits. In neuroscience, this approach helps researchers examine how the nervous system encodes facial somatosensation and coordinates behaviors such as feeding, whisking, speech, and protective reflexes. Controlled skin-stretch stimuli can also reveal how sensory feedback shapes motor output, providing insight into mechanotransduction, sensorimotor integration, pain processing, and disorders affecting orofacial sensation or movement.

Orofacial Skin Stretch - Related Videos

Research

JoVE EoE - Neurophysiology

Obtaining Somatosensory Stimulation-Related Signals from Orofacial Skin Stretching

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2025

This video demonstrates the recording of somatosensory stimulation-related signals through orofacial skin stretch using an electroencephalography (EEG) cap equipped with electrodes to monitor brain activity and a robotic device that produces the skin stretch.

Somatosensory Event-related Potentials from Orofacial Skin Stretch Stimulation

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Cited by 4 •

2015

This paper introduces a method for obtaining somatosensory event-related potentials following orofacial skin stretch stimulation. The current method can be used to evaluate the contribution of somatosensory afferents to both speech production and speech perception.

Inducing Orofacial Neuropathic Pain in a Rat Model via Infraorbital Nerve Ligations

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2025

This video demonstrates the induction of orofacial neuropathic pain in a rat model by ligating the infraorbital nerve. This results in nerve damage and inflammation, causing abnormal pain signaling and mimicking chronic pain conditions, which can be used to study the orofacial pain assay.

Live Cell Imaging during Mechanical Stretch

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Cited by 12 •

2015

A novel imaging protocol was developed using a custom motor-driven mechanical actuator to allow the measurement of real time responses to mechanical strain in live cells. Relevant to mechanobiology, the system can apply strains up to 20% while allowing near real-time imaging with confocal or atomic force microscopy.

Research

JoVE Journal - Behavior
Free Sample

Use of the Operant Orofacial Pain Assessment Device (OPAD) to Measure Changes in Nociceptive Behavior

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Cited by 42 •

2013

We present a user-friendly, high-throughput operant system for the evaluation of pain behaviors in awake, conscious rodents. The Orofacial Pain Assessment Device (OPAD) can assess pain through a reward/conflict paradigm thus providing a more humane way of testing. This protocol will yield more clinically relevant and translational data from rodents.

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