Immune Cell Function

Immune cell function encompasses how specialized cells detect, communicate about, and respond to threats such as pathogens, abnormal cells, and damaged tissue. Innate immune cells recognize conserved molecular patterns and act rapidly through phagocytosis, inflammatory signaling, and cytotoxic activity, while adaptive lymphocytes use antigen-specific receptors to produce antibodies, coordinate responses, and establish memory. In immunology and infection research, these coordinated activities help explain host defense, immune evasion, inflammation, and disease progression. Understanding immune cell function supports vaccine development, infection control, diagnostics, and therapies that strengthen or regulate immune responses.

Immune Cell Function - Related Videos

Research

JoVE Journal - Immunology and Infection

Isolation of Functional Cardiac Immune Cells

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Cited by 9 •

2011

This method for isolating functional immune cells from the heart provides an alternative to the conventional methods of collagenase digestion, which causes unwanted immune cell activation, resulting in a decreased responsiveness of these cells. Our method of isolation yields functional cardiac immune cells by avoiding problems associated with enzymatic digestion.

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

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Cited by 30 •

2016

We have established a technique for the isolation, phenotypic characterization and functional analysis of immune cells from murine gingiva.

A Barcoding Assay for Phenotypic and Functional Characterization of Immune Cells

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2025

This video highlights a single-cell proteomic method that employs heavy-metal-conjugated antibodies for distinct cell barcoding. Subsequently, immunostaining and mass cytometry are applied to evaluate immune phenotypic and functional alterations in human whole blood-derived immune cells.

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

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Cited by 8 •

2019

Herein we describe two approaches to characterize cell polarization events in B lymphocytes during the formation of an IS. The first, involves quantification of organelle recruitment and cytoskeleton rearrangements at the synaptic membrane. The second is a biochemical approach, to characterize changes in composition of the centrosome, which undergoes polarization to the immune synapse.

Education

JoVE Core - Anatomy and Physiology

Functions of the Lymphatic and Immune System

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2024

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria. The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...

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