Neurodevelopmental Disorders

Neurodevelopmental disorders are conditions that arise from differences or disruptions in brain development, affecting cognition, communication, behavior, learning, or motor function. They can result from complex interactions among genetic factors, prenatal influences, and other developmental conditions that alter neuronal differentiation, synaptic connectivity, or brain circuitry over time. In neuroscience, studying disorders such as autism spectrum disorder, attention-deficit/hyperactivity disorder, and intellectual disability helps link cellular and circuit-level mechanisms to clinical features. This research supports earlier identification, more precise diagnosis, and the development of targeted educational, behavioral, and medical interventions.

Neurodevelopmental Disorders - Related Videos

Research

JoVE Journal - Neuroscience

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

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Cited by 2 •

2015

We describe an immunohistochemistry protocol to study the profile of hippocampal neuron activation following exposure to a spatial learning task in a mouse model characterized by cognitive deficits of neurodevelopmental origin. This protocol can be applied to both genetic or pharmacological mouse models characterized by cognitive deficits.

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

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Cited by 46 •

2017

Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

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Cited by 77 •

2017

Behavioral testing is the gold standard for determining outcomes following brain injury, and can identify the presence of developmental disabilities in infants and children. Neurodevelopmental reflexes are an early indicator of these abnormalities. A host of easily accomplished developmental reflex tests in the neonatal rodent were developed and described here.

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay

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2024

This protocol explains how to measure the effect of genetic variation associated with neurodevelopmental disorders on deubiquitylating enzyme activity by combining recombinant protein purification with ubiquitin chain cleavage assays.

Education

JoVE Science Education - Psychology

Executive Function in Autism Spectrum Disorder

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2023

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California Attention, working-memory, planning, impulse control, inhibition, and mental flexibility are important components of human cognition that are often referred to as executive functions. Autism spectrum disorder is a developmental disorder that is characterized by impairments in social interaction, communication, and repetitive behaviors. It is a disorder that lasts a lifetime, and is thought to affect...

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