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Developmental Biology

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Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
 

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Article DOI: 10.3791/55372
April 14th, 2017

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Summary April 14th, 2017

Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.

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