İnme Preklinik Değerlendirme Ağı Tromboembolik İnme ve Trombolizli Çok Laboratuvarlı Modeli: TE-MCAo

932 görüntülenme

06:38 dk.

19 Aralık 2025

932 görüntülenme

¹Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine of USC, ²Department of Neurosurgery, Keck School of Medicine of USC, ³Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, ⁴Department of Internal Medicine, Division of Hematology, Oncology and Blood & Marrow Transplantation, Carver College of Medicine, University of Iowa, ⁵Departments of Neurology & Neurosurgery, Carver College of Medicine, Department of Epidemiology, College of Public Health, University of Iowa, ⁶The Medical College of Georgia at Augusta University, ⁷Department of Anesthesiology, Duke University, ⁸University of California, San Diego, ⁹Department of Neurology, Yale University, ¹⁰Neurovascular Research Unit, Massachusetts General Hospital, ¹¹Laboratory of NeuroImaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute of the Keck School of Medicine of USC, ¹²Department of Neurology, Keck School of Medicine of USC

Tromboembolik inmeyi simüle etmek için, heterolog fare kanından hazırlanan embolileri orta beyin arterine enjekte edildi ve ardından rekanalizasyon için sistemik tromboliz uygulandı. Bu model versiyonu, çoklu laboratuvar ağında kullanılmak üzere optimize edilmiştir ve birden fazla aday tedavi yönteminin test edilmesini destekler.