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Murine Model for Parkinson's Disease

Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test

Article DOI: 10.3791/1376
January 15th, 2010


Summary January 15th, 2010

Parkinson disease is caused by loss of dopaminergic innervation to the striatum, which can be experimentally induced by 6-OH-dopamine. We describe how to perform a stereotaxic lesion and to monitor apomorphine-induced rotational behavior in mice. This model is useful and reliable for testing new therapies for Parkinson disease.

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