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Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
JoVE Journal
Immunology and Infection
This content is Free Access.
JoVE Journal Immunology and Infection
Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

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10:09 min

January 03, 2012

DOI:

10:09 min
January 03, 2012

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Summary

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An in vitro model for cerebral malaria sequestration is described1. Plasmodium falciparum infected red blood cells are selected for binding to immortalized human brain microvascular endothelial cells. The selected parasites show a distinct phenotype. The selection process can be applied using various P. falciparum strains and endothelial cell lines.

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