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JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
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Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Article DOI: 10.3791/3122
January 3rd, 2012 •
1, 1
1Centre for Immunity, Infection and Evolution, University of Edinburgh

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January 3rd, 2012

An in vitro model for cerebral malaria sequestration is described1. Plasmodium falciparum infected red blood cells are selected for binding to immortalized human brain microvascular endothelial cells. The selected parasites show a distinct phenotype. The selection process can be applied using various P. falciparum strains and endothelial cell lines.

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