Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Nicolas Guerout; Alexandre Paviot; Nicolas Bon-Mardion; Axel Honor&#233;; Rais OBongo; C&#233;lia Duclos; Jean-Paul Marie

doi:10.3791/50590

Journal

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Neuroscience

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Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

11,716 Views

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10:33 min

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February 23, 2014

DOI:

10.3791/50590-v

DOI:

10.3791/50590-v

•

10:33 min

February 23, 2014

•

4 Views

Nicolas Guerout^1,2, Alexandre Paviot^1,3, Nicolas Bon-Mardion^1,3, Axel Honoré¹, Rais OBongo^1,4, Célia Duclos¹, Jean-Paul Marie^1,3

¹UPRES EA3830, Institute for Research and Innovation in Biomedicine,University of Rouen, ²Neuroscience,Karolinska Institutet, ³Otorhinolaryngology, Head and Neck Surgery Department,Rouen University Hospital, ⁴Otorhinolaryngology, Head and Neck Surgery Department,Amiens University Hospital

Summary

Olfactory ensheathing cells (OECs) are neural crest cells which allow growth of the primary olfactory neurons. This specific property can be used for cellular transplantation. We present here a model of cellular transplantation based on the use of OECs in a laryngeal nerve injury model.