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Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
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JoVE Journal Neuroscience
Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

DOI:
10.3791/61128-v

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09:39 min

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July 14, 2020

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, , ,
1Department of Bioengineering,University of Texas at Dallas, 2School of Behavioral and Brain Sciences,University of Texas at Dallas, 3Texas Biomedical Device Center,University of Texas at Dallas

Chapters

  • 00:04Introduction
  • 01:05Stimulating Cuff Electrode Fabrication
  • 05:58Device Usage
  • 06:50Results: Chronic Vagus Nerve Stimulation in Awake Behaving Rats
  • 09:00Conclusion

Summary

Automatic Translation

Automatic Translation

Existing approaches for constructing chronically implantable peripheral nerve cuff electrodes for use in small rodents often require specialized equipment and/or highly trained personnel. In this protocol we demonstrate a simple, low-cost approach for fabricating chronically implantable cuff electrodes, and demonstrate their effectiveness for vagus nerve stimulation (VNS) in rats.

Tags

Keywords: Peripheral Nerve StimulationChronic ImplantationRatsCuff ElectrodesPreclinical StudiesNerve StimulationStroke RecoveryNerve DysfunctionPolymer TubingSutureUV Cure AdhesivePlatinum Iridium Wire Leads

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