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JoVE Journal
Biology

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Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
 

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Article DOI: 10.3791/53318
December 10th, 2015

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Summary December 10th, 2015

Nuclear envelope proteins play a central role in many basic biological processes and have been implicated in a variety of human diseases. This protocol describes a new Cre/Lox-based mouse model that allows for the spatiotemporal control of LINC complexes disruption.

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