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An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation
 

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

Article DOI: 10.3791/57857
June 2nd, 2018

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Summary June 2nd, 2018

This protocol shows how to set up a reliable HFS method in mice. Neurons throughout the hippocampal dentate gyrus are electrically stimulated by HFS directly and indirectly in vivo. Neuronal activity and molecular signaling are examined by c-fos and Notch1 immunofluorescent staining, respectively; neurogenesis is quantified by bromodeoxyuridine labeling assay.

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