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JoVE Journal
Biochemistry

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Using High Content Imaging to Quantify Target Engagement in Adherent Cells
 

Using High Content Imaging to Quantify Target Engagement in Adherent Cells

Article doi: 10.3791/58670
November 29th, 2018

Summary November 29th, 2018

Measurements of drug target engagement are central to effective drug development and chemical probe validation. Here, we detail a protocol for measuring drug-target engagement using high content imaging in a microplate-compatible adaption of the cellular thermal shift assay (CETSA).

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