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Bioluminescent Optogenetics 2.0

Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo

Article DOI: 10.3791/62850-v 07:19 min August 4th, 2021
August 4th, 2021



Bioluminescence-light emitted by a luciferase enzyme oxidizing a small-molecule substrate, a luciferin-can be harnessed to activate photosensory proteins, thereby adding another dimension to light stimulation and enabling the manipulation of a multitude of light-mediated functions in cells across temporal and spatial scales.



Bioluminescent Optogenetics Genetically Encoded Light Sources Biological Functions Networks Cells Bioluminescence Luciferin Stock CTZ Solvent Light Exposure Fiber Optics Light Stimulation Cell Culture Medium Concentration Incubation Red Light Darkness Monitor Light Emission Photograph
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