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Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

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09:43 min

October 05, 2021

DOI:

09:43 min
October 05, 2021

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Summary

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The methods described here outline a procedure used to optogenetically reverse cocaine-induced plasticity in a behaviorally-relevant circuit in rats. Sustained low-frequency optical stimulation of thalamo-amygdala synapses induces long-term depression (LTD). In vivo optogenetically-induced LTD in cocaine-experienced rats resulted in the subsequent attenuation of cue-motivated drug seeking.

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