Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

Ruoxi Liao; Mingyuan He; Donghong Hu; Chengzheng Gong; Huiying Du; Hairuo Lin; Huijun Sun

doi:10.3791/63508

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Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

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Medicine

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JoVE Journal Medicine

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

3,043 Views

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10:18 min

•

February 01, 2022

DOI:

10.3791/63508-v

DOI:

10.3791/63508-v

•

10:18 min

February 01, 2022

•

3014 Views

Ruoxi Liao¹, Mingyuan He², Donghong Hu², Chengzheng Gong¹, Huiying Du¹, Hairuo Lin², Huijun Sun³

¹The First Clinical College of Dalian Medical University ²Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital,Southern Medical University ³College of Pharmacy,Dalian Medical University

Summary

There are several differences between the right and left ventricles. However, the pathophysiology of right ventricular infarction (RVI) has not been clarified. In the present protocol, a reproducible method for RVI mouse model generation is introduced, which may provide a means to explain the mechanism of RVI.