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Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
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JoVE Journal Medicine
Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

DOI:
10.3791/63508-v

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10:18 min

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February 01, 2022

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, , , , , ,
1The First Clinical College of Dalian Medical University, 2Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital,Southern Medical University, 3College of Pharmacy,Dalian Medical University

Chapters

  • 00:04Introduction
  • 00:54Preparation for Surgery
  • 01:37Permanent Ligation of the Right Coronary Artery
  • 03:03Echocardiographic Assessment of the RV (Right Ventricle) Function After Surgery
  • 05:25Invasive Measurements of RV Hemodynamic
  • 06:43Coronary Vascular Cast Using a Vascular Casting Agent
  • 07:49Results: Electrocardiography, Echocardiography and Histological Assessment After Right Coronary Artery Ligation
  • 09:48Conclusion

Summary

Automatic Translation

Automatic Translation

There are several differences between the right and left ventricles. However, the pathophysiology of right ventricular infarction (RVI) has not been clarified. In the present protocol, a reproducible method for RVI mouse model generation is introduced, which may provide a means to explain the mechanism of RVI.

Tags

Keywords: Right Ventricular InfarctionRight Coronary Artery LigationMouse ModelMyocardial InfarctionIschemiaECGSurgical ProcedureUltrasound Imaging

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