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JoVE Journal Medicine
A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery
 

A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery

Article doi: 10.3791/51329
April 10th, 2014 •
1, 1, 1, 1
1Davis Heart & Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University

Summary
Automatic Translation
April 10th, 2014

We introduce a surgical method to induce experimental ischemia/reperfusion (I/R) injury to simulate myocardial infarction (MI) in mouse models that allows for more clarity in positioning of the ligation on the left anterior descending artery (LAD) to increase the reproducibility of MI experiments in mice.

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