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Automated Processor for Clinical-Scale CAR-T Cell Manufacturing

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Fabricação de células T do receptor de antígeno quimérico em um processador de células automatizado

JoVE Journal
Medicine

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JoVE Journal Medicine

Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor

Fabricação de células T do receptor de antígeno quimérico em um processador de células automatizado

Automated Processor for Clinical-Scale CAR-T Cell Manufacturing

DOI:

10.3791/65488-v

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01:25 min

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August 18, 2023

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Rene Machietto, Nicholas Giacobbe, Jessica Perazzelli, Ted J. Hofmann, Allison Barz Leahy³, Stephan A. Grupp^2,3, Yongping Wang^3,4, Stephan Kadauke^3,4

¹Cell and Gene Therapy Laboratory, Department of Pathology and Laboratory Medicine,Children’s Hospital of Philadelphia, ²Division of Oncology, Department of Pediatrics,Children’s Hospital of Philadelphia, ³Perelman School of Medicine at the University of Pennsylvania, ⁴Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine,Children’s Hospital of Philadelphia

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Keywords: CAR-T Cell Manufacturing Automated Cell Processing Closed System Semi-automated Customizable Protocol Cost-effective Cell And Gene Therapy Immunotherapy CliniMACS Prodigy T Cell Transduction CGMP Compliance IND Application

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