The social threat-safety test allows a simultaneous assessment of social avoidance development as a measurement of aversive conditioned learning and social threat-safety discrimination ability, both utilized to identify stress-susceptible and stress-resilient individuals within a single group of chronically socially defeated male mice.
Ayash, S., Müller, M., Schmitt, U. Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes. J. Vis. Exp. (202), e65640, doi:10.3791/65640 (2023).