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Immunogenicity Enhancement by Mycobacterium paratuberculosis in Autoimmune Encephalomyelitis

May 12, 2023
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Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis (Video) | JoVE

02:51 min
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Mycobacterial Antigen Preparation (Video) | JoVE

01:38 min
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Preparation and Injection of Myelin Oligodendrocyte Glycoprotein (MOG35-55) Emulsion (Video) | JoVE

03:05 min
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1Department of Neurology,Juntendo University, 2Biomedical Research Core Facilities,Juntendo University, 3Neurodegenerative Disorders Collaborative laboratory,RIKEN Center for Brain Science

Summary

Automatic Translation

Here, we present an alternative protocol to actively induce experimental autoimmune encephalomyelitis in C57BL/6 mice, using the immunogenic epitope myelin oligodendrocyte glycoprotein (MOG)35-55 suspended in incomplete Freund’s adjuvant containing the heat-killed Mycobacterium avium subspecies paratuberculosis.

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