1Department of Molecular Craniofacial Embryology, Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University, 2Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University, 3Department of Regenerative and Reconstructive Dental Medicine, Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University
Bone therapy via endochondral ossification by implanting artificial cartilage tissue produced from mesenchymal stem cells has the potential to circumvent the drawbacks of conventional therapies. Hyaluronic acid hydrogels are effective in scaling up uniformly differentiated cartilage grafts as well as creating integrated bone with vascularization between fused grafts in vivo.
