Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration (Video) | JoVE

Shintaro Yamazaki; Yujing Lin; Eriko Marukawa; Masa-Aki Ikeda

doi:10.3791/65573

Artificial Cartilage Implants for Bone Regeneration via Endochondral Ossification

July 14th, 2023

Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration (Video) | JoVE

02:13 min

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Preparation and In Vitro Differentiation of Mesenchymal Stem Cell-Encapsulated Hydrogels for Bone Formation (Video) | JoVE

04:06 min

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Shintaro Yamazaki^1,2, Yujing Lin³, Eriko Marukawa³, Masa-Aki Ikeda^1,3

¹Department of Molecular Craniofacial Embryology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, ²Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, ³Department of Regenerative and Reconstructive Dental Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

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Bone therapy via endochondral ossification by implanting artificial cartilage tissue produced from mesenchymal stem cells has the potential to circumvent the drawbacks of conventional therapies. Hyaluronic acid hydrogels are effective in scaling up uniformly differentiated cartilage grafts as well as creating integrated bone with vascularization between fused grafts in vivo.

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Artificial Cartilage Implants for Bone Regeneration via Endochondral Ossification

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