Hubert Schorle Department of Developmental Pathology Institute of Pathology, University of Bonn Medical School Biography Publications Institution JoVE Articles Hubert Schorle has not added a biography. If you are Hubert Schorle and would like to personalize this page please email our Author Liaison for assistance. Publications SOX2 is Essential for in Vivo Reprogramming of Seminoma-like TCam-2 Cells to an Embryonal Carcinoma-like Fate Oncotarget. Jun, 2016 | Pubmed ID: 27283990 Tpbpa-Cre-mediated Deletion of TFAP2C Leads to Deregulation of Cdkn1a, Akt1 and the ERK Pathway, Causing Placental Growth Arrest Development (Cambridge, England). Mar, 2016 | Pubmed ID: 26811378 Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts Cell Stem Cell. Nov, 2015 | Pubmed ID: 26412560 BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency Via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma PLoS Genetics. Jul, 2015 | Pubmed ID: 26226633 Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta Biology of Reproduction. Aug, 2015 | Pubmed ID: 26063869 Co-existence of Intact Stemness and Priming of Neural Differentiation Programs in MES Cells Lacking Trim71 Scientific Reports. 2015 | Pubmed ID: 26057209 Injury-induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics Neuron. May, 2015 | Pubmed ID: 25937169 Reference Gene Validation for RT-qPCR, a Note on Different Available Software Packages PloS One. 2015 | Pubmed ID: 25825906 Derivation and Maintenance of Murine Trophoblast Stem Cells Under Defined Conditions Stem Cell Reports. Feb, 2014 | Pubmed ID: 24527396 Analysis of TET Expression/activity and 5mC Oxidation During Normal and Malignant Germ Cell Development PloS One. 2013 | Pubmed ID: 24386123 Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice PloS One. 2013 | Pubmed ID: 23967156 Fetuin-B, a Liver-derived Plasma Protein is Essential for Fertilization Developmental Cell. Apr, 2013 | Pubmed ID: 23562279 Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2012 | Pubmed ID: 22760542 Connexin 31 (GJB3) Deficiency in Mouse Trophoblast Stem Cells Alters Giant Cell Differentiation and Leads to Loss of Oxygen Sensing Biology of Reproduction. Aug, 2012 | Pubmed ID: 22623621 The Role of Transcription Factor Tcfap2c/TFAP2C in Trophectoderm Development Reproductive Biomedicine Online. Jul, 2012 | Pubmed ID: 22560121 Establishment of a Versatile Seminoma Model Indicates Cellular Plasticity of Germ Cell Tumor Cells Genes, Chromosomes & Cancer. Jul, 2012 | Pubmed ID: 22489004 PDGF Signalling Controls Age-dependent Proliferation in Pancreatic β-cells Nature. Oct, 2011 | Pubmed ID: 21993628 The Seminoma Cell Line TCam-2 is Sensitive to HDAC Inhibitor Depsipeptide but Tolerates Various Other Chemotherapeutic Drugs and Loss of NANOG Expression Genes, Chromosomes & Cancer. Dec, 2011 | Pubmed ID: 21987446 Lactogenic Differentiation of HC11 Cells is Not Accompanied by Downregulation of AP-2 Transcription Factor Genes BMC Research Notes. 2011 | Pubmed ID: 21906301 Transgenic Overexpression of Tcfap2c/AP-2gamma Results in Liver Failure and Intestinal Dysplasia PloS One. 2011 | Pubmed ID: 21779369 Lineage Conversion of Murine Extraembryonic Trophoblast Stem Cells to Pluripotent Stem Cells Molecular and Cellular Biology. Apr, 2011 | Pubmed ID: 21300784 NANOG Promoter Methylation and Expression Correlation During Normal and Malignant Human Germ Cell Development Epigenetics : Official Journal of the DNA Methylation Society. Jan, 2011 | Pubmed ID: 20930529 Interference with Activator Protein-2 Transcription Factors Leads to Induction of Apoptosis and an Increase in Chemo- and Radiation-sensitivity in Breast Cancer Cells BMC Cancer. 2010 | Pubmed ID: 20459791 The Transcription Factor TCFAP2C/AP-2gamma Cooperates with CDX2 to Maintain Trophectoderm Formation Molecular and Cellular Biology. Jul, 2010 | Pubmed ID: 20404091 Loss of Transcription Factor AP-2gamma/TFAP2C Impairs Branching Morphogenesis of the Murine Mammary Gland Developmental Dynamics : an Official Publication of the American Association of Anatomists. Mar, 2010 | Pubmed ID: 20131354 Critical Function of AP-2 Gamma/TCFAP2C in Mouse Embryonic Germ Cell Maintenance Biology of Reproduction. Jan, 2010 | Pubmed ID: 19776388 AP2gamma Regulates Basal Progenitor Fate in a Region- and Layer-specific Manner in the Developing Cortex Nature Neuroscience. Oct, 2009 | Pubmed ID: 19749747 AP-2alpha Regulates Migration of GN-11 Neurons Via a Specific Genetic Programme Involving the Axl Receptor Tyrosine Kinase BMC Biology. 2009 | Pubmed ID: 19463168 Loss of Connexin43-mediated Gap Junctional Coupling in the Mesenchyme of Limb Buds Leads to Altered Expression of Morphogens in Mice Human Molecular Genetics. Aug, 2009 | Pubmed ID: 19439426 An Activating Mutation in the PDGF Receptor Alpha Results in Embryonic Lethality Caused by Malformation of the Vascular System Developmental Dynamics : an Official Publication of the American Association of Anatomists. May, 2009 | Pubmed ID: 19334281 Autochthonous Liver Tumors Induce Systemic T Cell Tolerance Associated with T Cell Receptor Down-modulation Hepatology (Baltimore, Md.). Feb, 2009 | Pubmed ID: 19105207 Sustained Platelet-derived Growth Factor Receptor Alpha Signaling in Osteoblasts Results in Craniosynostosis by Overactivating the Phospholipase C-gamma Pathway Molecular and Cellular Biology. Feb, 2009 | Pubmed ID: 19047372 Expression of BLIMP1/PRMT5 and Concurrent Histone H2A/H4 Arginine 3 Dimethylation in Fetal Germ Cells, CIS/IGCNU and Germ Cell Tumors BMC Developmental Biology. 2008 | Pubmed ID: 18992153 Lactogenic Differentiation of HC11 Cells is Not Accompanied by Downregulation of AP-2 Transcription Factor Genes BMC Research Notes. 2008 | Pubmed ID: 18710545 Gene Expression Profiling Identifies New Biological Markers of Neoplastic Germ Cells Anticancer Research. Sep-Oct, 2007 | Pubmed ID: 17970049 Enhanced Purification of Cell-permeant Cre and Germline Transmission After Transduction into Mouse Embryonic Stem Cells Genesis (New York, N.Y. : 2000). Aug, 2007 | Pubmed ID: 17661398 Essential Role of Ubiquitin-specific Protease 8 for Receptor Tyrosine Kinase Stability and Endocytic Trafficking in Vivo Molecular and Cellular Biology. Jul, 2007 | Pubmed ID: 17452457 Deficiency in the LIM-only Protein Fhl2 Impairs Skin Wound Healing The Journal of Cell Biology. Apr, 2007 | Pubmed ID: 17420295 Establishment and Controlled Differentiation of Neural Crest Stem Cell Lines Using Conditional Transgenesis Differentiation; Research in Biological Diversity. Sep, 2007 | Pubmed ID: 17381545 Spatial Expression of Germ Cell Markers During Maturation of Human Fetal Male Gonads: an Immunohistochemical Study Human Reproduction (Oxford, England). Feb, 2006 | Pubmed ID: 16210381 The AP-2 Family of Transcription Factors Genome Biology. 2005 | Pubmed ID: 16420676 Cell-specific Deletion of Glucosylceramide Synthase in Brain Leads to Severe Neural Defects After Birth Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16109770 Mice Transgenic for NPM-ALK Develop Non-Hodgkin Lymphomas Anticancer Research. Sep-Oct, 2005 | Pubmed ID: 16101126 A Mouse Model for Cystic Biliary Dysgenesis in Autosomal Recessive Polycystic Kidney Disease (ARPKD) Hepatology (Baltimore, Md.). May, 2005 | Pubmed ID: 15830394 Dual Role of AP-2gamma in ErbB-2-induced Mammary Tumorigenesis Breast Cancer Research and Treatment. Apr, 2005 | Pubmed ID: 15830141 Transcription Factor AP-2gamma, a Novel Marker of Gonocytes and Seminomatous Germ Cell Tumors International Journal of Cancer. Journal International Du Cancer. Jun, 2005 | Pubmed ID: 15700319 Distinct Spatial Expression Patterns of AP-2alpha and AP-2gamma in Non-neoplastic Human Breast and Breast Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2005 | Pubmed ID: 15467710 Towards Dissecting the Complexity of the AP-1 (activator Protein 1) Family Advances in Experimental Medicine and Biology. 2004 | Pubmed ID: 15503467 Cell Type-specific Conditional Regulation of the C-myc Proto-oncogene by Combining Cre/loxP Recombination and Tamoxifen-mediated Activation Genesis (New York, N.Y. : 2000). Mar, 2004 | Pubmed ID: 15048812 Starvation Response in Mouse Liver Shows Strong Correlation with Life-span-prolonging Processes Physiological Genomics. Apr, 2004 | Pubmed ID: 14762175 Transcription Factor AP-2gamma Stimulates Proliferation and Apoptosis and Impairs Differentiation in a Transgenic Model Molecular Cancer Research : MCR. Oct, 2003 | Pubmed ID: 14573793 Differential Role of P300 and CBP Acetyltransferase During Myogenesis: P300 Acts Upstream of MyoD and Myf5 The EMBO Journal. Oct, 2003 | Pubmed ID: 14517256 Cloning, Expression and Characterization of the Murine Efemp1, a Gene Mutated in Doyne-Honeycomb Retinal Dystrophy Gene Expression Patterns : GEP. Aug, 2003 | Pubmed ID: 12915309 Dynamic Expression of Krüppel-like Factor 4 (Klf4), a Target of Transcription Factor AP-2alpha During Murine Mid-embryogenesis The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology. Aug, 2003 | Pubmed ID: 12845703 Terminal Renal Failure in Mice Lacking Transcription Factor AP-2 Beta Laboratory Investigation; a Journal of Technical Methods and Pathology. Apr, 2003 | Pubmed ID: 12695560 Mutation of the SBF2 Gene, Encoding a Novel Member of the Myotubularin Family, in Charcot-Marie-Tooth Neuropathy Type 4B2/11p15 Human Molecular Genetics. Feb, 2003 | Pubmed ID: 12554688 Exencephaly in a Subset of Animals Heterozygous for AP-2alpha Mutation Teratology. May, 2002 | Pubmed ID: 11967920 Transcription Factor Gene AP-2 Gamma Essential for Early Murine Development Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940672 Conditional Inactivation of Transcription Factor AP-2gamma by Using the Cre/loxP Recombination System Genesis (New York, N.Y. : 2000). Feb, 2002 | Pubmed ID: 11857798 A Subtractive Gene Expression Screen Suggests a Role of Transcription Factor AP-2 Alpha in Control of Proliferation and Differentiation The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11741941 ट्रोफोब्लास्ट स्टेम कोशिकाओं में Murine भ्रूण fibroblasts की प्रत्यक्ष रूपांतरण के लिए प्रोटोकॉल Caroline Kubaczka1, Hubert Schorle1 1Department of Developmental Pathology, Institute of Pathology, University of Bonn Medical School 发育生物学 चिकी भ्रूण निकालें के murine तंत्रिका शिखा स्टेम सेल की खेती के लिए उत्पादन Kristian Pajtler*1, Anna Bohrer*1, Jochen Maurer2, Hubert Schorle2, Alexander Schramm1, Angelika Eggert1, Johannes Hubertus Schulte1 1Department of Pediatric Oncology, University Children's Hospital Essen, 2Department of Developmental Pathology, Bonn Medical School, Institute of Pathology JoVE 2380 神经科学
ट्रोफोब्लास्ट स्टेम कोशिकाओं में Murine भ्रूण fibroblasts की प्रत्यक्ष रूपांतरण के लिए प्रोटोकॉल Caroline Kubaczka1, Hubert Schorle1 1Department of Developmental Pathology, Institute of Pathology, University of Bonn Medical School 发育生物学
चिकी भ्रूण निकालें के murine तंत्रिका शिखा स्टेम सेल की खेती के लिए उत्पादन Kristian Pajtler*1, Anna Bohrer*1, Jochen Maurer2, Hubert Schorle2, Alexander Schramm1, Angelika Eggert1, Johannes Hubertus Schulte1 1Department of Pediatric Oncology, University Children's Hospital Essen, 2Department of Developmental Pathology, Bonn Medical School, Institute of Pathology JoVE 2380 神经科学
