Heart Pacing
Heart Pacing - Related Videos
06:14
Translational Rabbit Model of Chronic Cardiac Pacing
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2023
We present a minimally invasive leporine model of long-term cardiac pacing that can be utilized for artificial pacing and heart failure development in preclinical studies.
07:49
A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
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2023
The present protocol describes obtaining the pressure-volume relationship through transesophageal pacing, which serves as a valuable tool in evaluating diastolic function in mouse models of heart failure.
07:47
A Novel Ex vivo Culture Method for the Embryonic Mouse Heart
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Cited by 12 •
2013
Developmental studies in the mouse are hampered by the inaccessibility of the embryo during gestation. To promote the long-term culture of the embryonic heart at late stages of gestation, we developed a protocol in which the excised heart is cultured in a semi-solid, dilute Matrigel.
07:27
Implantation of Total Artificial Heart in Congenital Heart Disease
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Cited by 40 •
2014
This is a case report of a patient with congenitally corrected transposition of the great arteries (CCTGA) who received a total artificial heart (TAH) as a bridge to heart transplant. The TAH was successfully implanted with modifications to accommodate the patient's congenitally malformed heart.
12:45
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Cited by 2 •
2017
The establishment of a chronic asynchronous heart failure (HF) model by rapid pacing combined with left bundle branch ablation is presented. Two-dimensional speckle tracking imaging and aortic velocity time integral are applied to validate this stable HF model with left ventricular asynchrony and the benefits of cardiac resynchronization therapy.
FAQs
Pulse timing establishes when cardiac muscle is depolarized, so contractions can be initiated or regulated rather than left entirely to an impaired natural rhythm. Appropriate timing supports coordinated contraction and an appropriate heart rate. This principle connects electrical control with circulation, making timing central to pacemaker and engineered-heart research.
Depolarization is the electrical change that allows a delivered pulse to trigger cardiac muscle contraction. Its importance lies in linking the device’s electrical output to a mechanical response: the heart contracts in a coordinated way instead of receiving stimulation without a functional consequence. This relationship is central to evaluating cardiac function and conduction.
Heart pacing actively delivers electrical pulses, whereas cardiac monitoring systems provide a way to assess cardiac function. Engineered heart tissues serve another role by supporting research on electrical conduction and arrhythmias. Together, these approaches distinguish intervention from observation and experimental modeling, helping bioengineers evaluate cardiac behavior from complementary perspectives.
A pacing setup centers on a device or electrode that delivers timed electrical pulses to cardiac muscle. The important design considerations are how stimulation reaches the tissue and how its timing supports an appropriate rate and coordinated contraction. In bioengineering, these requirements guide pacemaker design and the development of more responsive implantable devices.
A conceptual pacing workflow applies controlled electrical stimulation and then considers whether the resulting contractions are coordinated and whether heart rate is supported. Cardiac monitoring systems help evaluate cardiac function during this assessment. The relevant outcome is not merely pulse delivery, but the resulting effect on rhythm, contraction, and circulation.
Pacing is especially relevant when rhythm disorders impair the heart’s natural rhythm and threaten adequate circulation. In bioengineering, the same principle informs pacemaker development, cardiac monitoring systems, and engineered heart tissues. These applications support studies of conduction and arrhythmias, evaluation of cardiac function, therapy testing, and development of more responsive implantable devices.