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Journal / Cancer Research / Sammenligne metastatisk klar celle nyrecelle…
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JoVE Journal Cancer Research
Sammenligne metastatisk klar celle nyrecelle karsinom modell etablert i mus nyre og på kylling chorioallantoic membran
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Sammenligne metastatisk klar celle nyrecelle karsinom modell etablert i mus nyre og på kylling chorioallantoic membran

Article DOI: 10.3791/60314-v • 05:36 min • February 8th, 2020
February 8th, 2020 •
*1, *1, 2, 3, 4, 5, 6, 7, 1, 1,8
1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 2Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 3Department of Bioengineering, Hanyang University, 4Department of Ecology and Evolutionary Biology, University of California, Los Angeles, 5Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 6School of Life Sciences, Beijing Normal University, 7Department of Urology, West China Hospital, Sichuan University, 8Department of Urology, David Geffen School of Medicine, University of California, Los Angeles
* These authors contributed equally

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Metastatisk klart celle nyrecellekarsinom er en sykdom uten en omfattende dyremodell for grundig preklinisk undersøkelse. Denne protokollen illustrerer to nye dyremodeller for sykdommen: den ortotopisk implanterte musemodellen og kyllingkorioallantoisk membranmodell, som begge viser lungemetastase som ligner kliniske tilfeller.

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Kreftforskning Utgave 156 nyrecellekarsinom metastase dyremodell nyreimplantasjon CAM VHL gensletting intratumoral heterogenitet
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