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Indurre lesioni acute al fegato nei ratti tramite Carbon Tetrachloride (CCl4) Esposizione attraverso un tubo orogastrico
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Indurre lesioni acute al fegato nei ratti tramite Carbon Tetrachloride (CCl4) Esposizione attraverso un tubo orogastrico

Article DOI: 10.3791/60695-v • 06:12 min • April 28th, 2020
April 28th, 2020 •
*1, *1, 2, 3, 1, 1, 4, 1, 1, 1
1Department of Anesthesiology and Critical Care, Soroka Medical Center, Ben-Gurion University of the Negev, 2Department of Anesthesiology, Yale University School of Medicine, 3Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 4Department of Ophthalmology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev
* These authors contributed equally

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Questo protocollo descrive un metodo comune e fattibile per indurre lesioni epatiche acute (ALI) tramite l'esposizione di CCl4 attraverso un tubo orogastrico. L'esposizione a CCl4 induce ALI attraverso la formazione di specie reattive dell'ossigeno durante la sua biotrasformazione nel fegato. Questo metodo viene utilizzato per analizzare la fisiopatologia di ALI ed esaminare diverse strategie eaptoprotettive.

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Medicina Emissione 158 lesione epatica acuta (ALI) tetracloruro di carbonio (CCl4) lesione epatica danni al fegato modello di ratto tossina
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