Chromic Gut Ligatures
Chromic Gut Ligatures - Related Videos
08:23
Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
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Cited by 154 •
2012
Due to the simplicity of surgery and the robust behavioural outcome, chronic constriction of the sciatic nerve is one of the pre-eminent animal models of neuropathic pain. Within 24 hrs following surgery, pain hypersensitivity is established and can be quantitatively measured using a von Frey aesthesiometer (mechanical test) and plantar analgesia meter (thermal test).
15:27
Extracting DNA from the Gut Microbes of the Termite (Zootermopsis Angusticollis) and Visualizing Gut Microbes
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Cited by 17 •
2007
This video illustrates the technique for extracting DNA from the species of microbes resident in the termite hindgut. The preparation of a wet mount slide, which is useful for visualizing the gut microbial community is also illustrated, and a tour through the species-rich gut environment is given.
08:22
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
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Cited by 14 •
2013
We describe a highly reproducible method for the permanent occlusion of a rodent major cerebral blood vessel. This technique can be accomplished with very little peripheral damage, minimal blood loss, a high rate of long-term survival, and consistent infarct volume commensurate with the human clinical population.
10:52
Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain
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Cited by 48 •
2015
This manuscript describes a rodent model to study trigeminal neuropathic pain. The methods described include surgical procedures to perform a chronic constriction injury of the rat’s infraorbital nerve and the post-surgical behavioral tests to measure the changes in spontaneous and evoked behavior that are indicative of persistent pain and allodynia.
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Cited by 4 •
2020
This article presents a protocol for establishing a ligature-induced model of murine periodontitis involving multiple maxillary molars, resulting in larger areas of the involved gingival tissue and bone for subsequent analysis as well as reduced animal usage. A technique to assess oral neutrophils in a manner analogous to human subjects is also described.
FAQs
Chromium salts make the collagen less vulnerable to enzymatic digestion, so the ligature retains useful strength longer than untreated collagen would. This delayed breakdown supports a temporary interval of tissue approximation or vessel occlusion. The treatment therefore aligns material persistence with the early phase of healing, when internal support may still be needed.
Absorption is influenced by both enzymatic breakdown and the local tissue response. Because those conditions can differ within the body, the material may not disappear at exactly the same rate in every use. This variability matters when clinicians select a temporary ligature, since its support must remain adequate while healing begins.
Its usefulness depends on the balance between resistance to enzymatic digestion and the time required for tissue healing. Chromium treatment slows material breakdown, while the collagen structure supplies the ligature itself. When support is needed only during an early healing interval, gradual loss of the material can provide assistance without requiring later removal.
The same ligature can serve different mechanical purposes according to how it is applied. It can hold soft tissues together so their edges remain approximated, or it can occlude a small blood vessel to control flow. These functions make the material relevant to procedures where temporary internal support is sufficient.
They may be useful when support is needed inside the body and removing the tie later would be difficult or unnecessary. Their absorbable nature allows the material to remain during the initial healing period and then gradually break down. This is especially relevant for internal soft-tissue closure and management of small vessels.
In medicine, these ligatures can close soft tissues, secure vessels, and manage sites where temporary internal support is appropriate. Their value comes from combining handling characteristics with predictable, delayed absorption. Clinicians must still consider that tissue response and absorption time can vary, which may affect how the material performs in a particular surgical setting.