Rapid Ventricular Pacing
Rapid Ventricular Pacing - Related Videos
06:14
Translational Rabbit Model of Chronic Cardiac Pacing
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2023
We present a minimally invasive leporine model of long-term cardiac pacing that can be utilized for artificial pacing and heart failure development in preclinical studies.
12:09
Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
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Cited by 14 •
2013
A methodology to estimate ventricular fiber orientations from in vivo images of patient heart geometries for personalized modeling is described. Validation of the methodology performed using normal and failing canine hearts demonstrate that that there are no significant differences between estimated and acquired fiber orientations at a clinically observable level.
14:39
Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
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Cited by 44 •
2014
Current knowledge on the cellular basis of cardiac diseases mostly relies on studies on animal models. Here we describe and validate a novel method to obtain single viable cardiomyocytes from small surgical samples of human ventricular myocardium. Human ventricular myocytes can be used for electrophysiological studies and drug testing.
12:45
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Cited by 2 •
2017
The establishment of a chronic asynchronous heart failure (HF) model by rapid pacing combined with left bundle branch ablation is presented. Two-dimensional speckle tracking imaging and aortic velocity time integral are applied to validate this stable HF model with left ventricular asynchrony and the benefits of cardiac resynchronization therapy.
07:24
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Cited by 34 •
2013
This article describes procedures for implanting a novel hydrogel in failing hearts and quantifying its effect on left ventricular wall stress and function. These procedures have been successfully applied in dogs and humans.
FAQs
Electrical impulses capture the ventricle and drive it at a rapid, controlled rate. The accelerated rhythm shortens diastolic filling time, so the ventricles receive less blood before contraction. This reduction in filling lowers stroke volume and creates a brief decrease in arterial pressure, producing a controlled hemodynamic state during the period of stimulation.
Ventricular capture means that the delivered electrical impulses successfully activate the ventricle. Without this response, the intended rapid ventricular rhythm and associated reduction in filling would not be produced reliably. Establishing capture therefore connects catheter output with the desired temporary change in ventricular motion, stroke volume, and arterial pressure.
Pacing rate and stimulation duration are the principal controllable variables identified for this technique. Increasing the rate can further shorten diastolic filling time, while extending stimulation can prolong the reduced-output state. Clinicians adjust both carefully to obtain sufficient procedural control while limiting hypotension and other potential complications.
A pacing catheter delivers electrical impulses to capture the ventricle, after which clinicians apply a rapid, controlled pacing rate for a brief interval. The rate and duration are selected to alter ventricular motion and hemodynamics during the relevant procedural step. Limiting the intervention to the necessary period helps reduce excessive hypotension and related risks.
During transcatheter aortic valve deployment, a brief reduction in ventricular output and arterial pressure can support procedural precision. Rapid ventricular pacing creates this state by limiting diastolic filling and stroke volume while the ventricle is driven at a controlled rate. Clinicians can therefore use the technique during the deployment phase without making the altered hemodynamics the permanent rhythm.
Beyond transcatheter aortic valve deployment, the technique is used during selected cardiac interventions and in some electrophysiology applications. Its value comes from briefly changing cardiac output and motion in a controlled manner. The approach is most relevant when a procedure benefits from a short, predictable hemodynamic interval and when rate and duration can be carefully managed.