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JoVE Journal
Cancer Research

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A Mimic of the Tumor Microenvironment

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Article DOI: 10.3791/54429-v 09:52 min September 20th, 2016
September 20th, 2016



We adapted a permeable microporous membrane insert to mimic the tumor microenvironment (TME). The model consists of a mixed cell culture, allows simplified generation of highly enriched individual cell populations without using fluorescent tagging or cell sorting, and permits studying intercellular communication within the TME under normal or stress conditions.


Keywords: Tumor Microenvironment In Vitro Coculture Model Intercellular Communication Cancer-associated Fibroblasts Therapeutic Agents Cell Populations Cell Culture Cell Dissociation Cell Seeding Cell Incubation
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