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Minimally Invasive Transverse Aortic Constriction in Mice

Article DOI: 10.3791/55293-v • 07:40 min • March 14th, 2017
March 14th, 2017 •
1, 2, 3, 1
1School of Biological Sciences, The University of Hong Kong, 2College of Arts and Science, New York University, 3Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University

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Summary
Automatic Translation

Minimally invasive transverse aortic constriction (MTAC) conserves the essentials of regular transverse aortic constriction (TAC) while eliminating the use of a ventilator with tracheal intubation. It proves to be a highly desirable method for high-throughput studies on left ventricular overload, particularly in translational studies.

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Minimally Invasive Transverse Aortic Constriction Left Ventricular Hypertrophy Surgical Procedure Artificial Ventilation Cardiology Field Myocardial Remodeling Cardiac Hypertrophy Apoptosis Fibrosis Left Ventricular Pressure Overload Technique Ventilator Tracheal Intubation Needle Holder 30-gauge Needles Cotton Applicators 27-gauge Needle Sedation Ointment Heated Pad Supine Position Surgical Tape Disinfect Alcohol Solution Wipes Povidone-iodine Solution Wipes Sterile Drape Ligation Procedure Midline Position
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