Gamma Irradiation
Gamma Irradiation - Related Videos
04:15
A Mouse Model of Fatigue Induced by Peripheral Irradiation
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Cited by 18 •
2017
We describe a method using targeted peripheral irradiation to induce fatigue-like behavior in mice. The selected non-lethal irradiation dose leads to a week-long reduction in voluntary wheel-running activity.
01:32
Evoked Gamma Oscillations for the Treatment of Alzheimer’s Disease
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2025
Begin with a patient diagnosed with Alzheimer’s disease, wearing a gamma therapy stimulation device.The device consists of an eye-set and headphones.Using the controller, activate the device to deliver auditory and visual stimulation.The visual component emits flickering light at a gamma frequency, while the auditory component produces synchronized sound pulses.Gamma oscillations are brain waves generated by synchronized neuronal firing, crucial for cognition and memory.In AD, these...
10:09
Planarian Immobilization, Partial Irradiation, and Tissue Transplantation
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Cited by 20 •
2012
An effective method for grafting tissue of defined and consistent size between planaria is described. Also included is a description of how the immobilization technique used for transplantation can be adapted, in conjunction with lead shields, for the partial irradiation of live animals.
11:24
Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
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Cited by 3 •
2015
A protocol to evaluate changes in DNA damage levels and DNA repair capacity that may be induced by chronic in vivo low dose irradiation in mouse spleen lymphocytes, by measuring phosphorylated histone H2AX, a marker of DNA double-strand breaks, using flow cytometry is presented.
03:40
UV Irradiation: A Method to Integrate Extrachromosomal Arrays
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2023
Microinjection of transgenes usually results in C. elegans strains with large extrachromosomal arrays, which result in variable expression and transmission of the transgene. UV Irradiation can induce chromosomal integration of the array and more stable transgene transmission.
FAQs
The outcome depends on three linked variables: dose, exposure conditions, and target resistance. A measured dose determines how much ionization occurs, while exposure conditions influence how radiation reaches the sample. Target organisms vary in resistance, so the same treatment may not produce the same level of inactivation across bacteria, viruses, and parasites.
Two pathways contribute to damage. Gamma-ray photons can injure nucleic acids directly, and they can also produce reactive species when radiation causes water radiolysis. These effects create lesions that interfere with microbial replication. Together, they explain why irradiation can inactivate organisms while allowing the material to receive a controlled, measured dose.
Nonreplicating preparations provide material that can be examined for immune recognition without retaining the ability to replicate. Gamma irradiation can inactivate bacteria, viruses, or parasites for this purpose. This approach also supports safer handling during pathogen research, linking radiation-based preparation to studies of how immune systems detect infectious targets.
Planning requires identifying the material or biological product, selecting an appropriate measured radiation dose, and defining the exposure conditions. The target organism's resistance must also be considered because it affects the treatment outcome. These parameters determine whether the goal is sterilizing equipment, inactivating a pathogen, or preparing nonreplicating research material.
The method is useful when equipment or biological products must be sterilized before use in research or infection-related work. It can also treat pathogen-containing materials by preventing microbial replication. The relevant outcome depends on the selected dose and exposure conditions, so treatment is connected directly to the material's intended use and the target's resistance.
In immunology and infection studies, irradiation can generate nonreplicating preparations from bacteria, viruses, or parasites. Researchers can then examine immune recognition while reducing the risk associated with handling replicating infectious material. The scientific value lies in combining safer pathogen research with controlled exposure conditions and a dose selected for the target organism.