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Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
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Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping

Article DOI: 10.3791/56478-v • 08:19 min • February 22nd, 2018
February 22nd, 2018 •
*1, *1, *1, 1, 2, 1
1Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 2Department of Biofunctional Informatics, Tokyo Medical and Dental University
* These authors contributed equally

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This protocol describes the electrophysiological evaluation of murine atria utilizing an optical mapping system with a high temporal and spatial resolution, including dual recordings of the membrane voltage and Ca2+ transient under programmed stimulation through a specialized electrode catheter.

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Electrophysiological Assessment Murine Atria High-resolution Optical Mapping Normal Sinus Rhythm Atrial Arrhythmia Electrical Stimulation Genetic Mutations Initiation Mechanism Maintenance Mechanism Langendorff Apparatus Perfusion Circuit Imaging Parameters Mouse Cannulation Heparin Treatment Anesthesia Reflex Test Supine Position Abdominal Wall Incision Diaphragm Incision Excision Of Heart And Adjacent Tissues Wash With PBS Ascending Aorta
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