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Biochemistry

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JoVE Journal Biochemistry
Fremgangsmåde til at identificere småmolekylære inhibitorer af protein-protein-vekselvirkning mellem HCN1 og TRIP8b
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Fremgangsmåde til at identificere småmolekylære inhibitorer af protein-protein-vekselvirkning mellem HCN1 og TRIP8b

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

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Samspillet mellem HCN kanaler og deres ekstra subunit er blevet identificeret som en terapeutisk mål i depression. Her, en fluorescenspolarisering-baseret fremgangsmåde til identifikation af småmolekylære inhibitorer af dette protein-protein-interaktion, er præsenteret.

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Biochemistry High-throughput screening drug discovery protein-protein interaktioner fluorescenspolarisering HCN TRIP8b
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