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Immunology and Infection

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JoVE Journal Immunology and Infection
Induzione di paralisi e di lesioni del sistema visivo in topi da specifiche cellule T per neuromielite ottica Autoantigen acquaporina-4
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Induzione di paralisi e di lesioni del sistema visivo in topi da specifiche cellule T per neuromielite ottica Autoantigen acquaporina-4

Article DOI: 10.3791/56185-v • 09:29 min • August 21st, 2017
August 21st, 2017 •
*1,2, *1, 1,2, 3, 3, 1, 4, 1,2
1Department of Neurology, University of California, 2Program in Immunology, University of California, 3Department of Neurology and Neurological Sciences, Stanford University, 4Department of Pathology, Stanford University
* These authors contributed equally

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Qui, presentiamo un protocollo per indurre l'infiammazione di paralisi e opticospinal di trasferimento di acquaporina-4 (AQP4)-specifiche cellule T da AQP4 topi- / - in topi WT. Inoltre, dimostriamo come utilizzare tomografia a coerenza ottica seriale per monitorare la disfunzione del sistema visivo.

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Immunologia problema 126 neuromielite ottica l'Acquaporina-4 flusso cytometry trasferimento adottivo di cellule T dell'autoimmunità CNS tomografia a coerenza ottica
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