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Polyethyleneimine-belagt jernoxid nanopartikler som et køretøj til levering af små interfererende RNA til makrofager In Vitro og In Vivo

Article DOI: 10.3791/58660-v • 09:36 min • February 5th, 2019
February 5th, 2019 •
*1, *2, 1, 1, 2, 2, 1
1Key Laboratory of Ministry of Education for Developmental Genes & Human Diseases, Institute of Life Sciences and School of Medicine, Southeast University, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials & Devices, School of Biological Science & Medical Engineering, Southeast University
* These authors contributed equally

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Vi beskriver en metode til at bruge polyethyleneimine (PEI)-belagt superparamagnetisk jernoxid nanopartikler til transfecting makrofager med siRNA. Disse nanopartikler kan effektivt levere siRNA til makrofager i in vitro og i vivo og stilhed target genekspression.

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Medicin spørgsmål 144 makrofag Transfektion nanopartikel siRNA levering polyethyleneimine køretøj genhæmning
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