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Polyethyleneimine-belagda järnoxid nanopartiklar som ett fordon för leverans av små störande RNA till makrofager In Vitro och In Vivo

Article DOI: 10.3791/58660-v • 09:36 min • February 5th, 2019
February 5th, 2019 •
*1, *2, 1, 1, 2, 2, 1
1Key Laboratory of Ministry of Education for Developmental Genes & Human Diseases, Institute of Life Sciences and School of Medicine, Southeast University, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials & Devices, School of Biological Science & Medical Engineering, Southeast University
* These authors contributed equally

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Vi beskriver en metod för att använda polyethyleneimine (PEI)-belagda superparamagnetiska järnoxid nanopartiklar för transfecting makrofager med siRNA. Dessa nanopartiklar kan effektivt leverera siRNA att makrofager in vitro- och in-vivo och tystnad mål genuttryck.

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Medicin fråga 144 makrofag transfection nanopartiklar siRNA delivery polyethyleneimine fordon nedtystning
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