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Positronutslippstomografi Avbildning av cellehandel: En metode for celleradiomerking

Article DOI: 10.3791/64117-v • 10:07 min • October 27th, 2023
October 27th, 2023 •
1, 2, 1
1Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, 2Department of Radiology, University of Colorado Anschutz Medical Campus

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Presentert her er en protokoll til radiolabel celler med en positronemisjonstomografi (PET) radioisotop, 89 Zr (t1/2 78,4 h), ved hjelp av en klar til bruk radiomerking synton, [89 Zr] Zr-p-isothiocyanatobenzyl-desferrioxamine ([89Zr] Zr-DBN). Radiomerking av celler med [89Zr]Zr-DBN tillater ikke-invasiv sporing og avbildning av administrerte radiomerkede celler i kroppen med PET i opptil 7 dager etter administrering.

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