Repeated Exposure Test
Repeated Exposure Test - Related Videos
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
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Cited by 7 •
2017
This study describes the successful generation of a new chronic obstructive pulmonary disease (COPD) animal model by repeatedly exposing mice to high concentrations of ozone.
09:50
Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
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Cited by 41 •
2015
The aim of this protocol is to expose human organotypic 3D bronchial and nasal tissue models to mainstream cigarette smoke (CS) at the air-liquid interface. The impact of CS on the tissues is then investigated using a cytochrome P450 activity assay, a cilia beating measurement, and a systems biology approach.
09:29
An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
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Cited by 45 •
2020
Described is the cell culture and exposure method of an in vitro bronchial model for realistic, repeated inhalation exposure to particles for toxicity testing.
10:11
Whole-Body Nanoparticle Aerosol Inhalation Exposures
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Cited by 51 •
2013
A whole-body nanoparticle aerosol inhalation exposure facility was constructed for nano-sized titanium dioxide (TiO2) inhalation toxicology studies. This system provides nano-TiO2 aerosol test atmospheres that have: 1) a steady mass concentration; 2) a homogenous composition free of contaminants; and 3) a stable particle size distribution during aerosol generation.
01:28
Infinitely Repeated Games
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2025
An infinitely repeated game is a scenario where players repeatedly engage in the same game without a predetermined end. This concept is crucial in understanding long-term interactions in various fields of the social sciences, including economics and international relations. Examples: Firms Setting Prices: Companies continuously adjust prices. Trade Negotiations: Countries consistently negotiate trade terms. Tit-for-Tat Strategy Cooperative Start: Players begin with a cooperative action,...
FAQs
Spacing exposures across a defined period allows investigators to examine whether effects build, persist, or emerge only after several contacts with the substance. The schedule also links observed changes to the amount and timing of exposure, helping distinguish a response associated with repeated dosing from an effect that might appear after only one exposure.
Multiple contacts can reveal cumulative effects, delayed responses, or altered sensitivity that may not be evident after one exposure. Comparing the two approaches helps investigators determine whether the response depends on exposure frequency or duration, rather than judging safety from an isolated observation. This distinction is relevant when evaluating longer-term tolerability and potential toxicity.
Clinical signs, laboratory measurements, and other health indicators provide complementary evidence about how the system responds over time. Reviewing these measures together can show whether changes are dose-related, delayed, or associated with altered sensitivity. In clinical research, this broader assessment supports a more complete interpretation than relying on a single health indicator or observation.
A study specifies a defined period and a controlled dosing or contact schedule, then tracks clinical signs, laboratory measurements, and other health indicators during that period. Investigators can compare observations across the exposure sequence to identify emerging or changing responses. This structured workflow supports consistent evaluation of cumulative, delayed, or dose-related effects.
In medication research, repeated exposure testing helps evaluate tolerability beyond the response to an isolated administration. Monitoring clinical signs, laboratory measurements, and other health indicators across the schedule can reveal changes that develop with continued dosing. Those findings can inform safer treatment designs by showing whether the exposure pattern is associated with cumulative effects, delayed responses, or altered sensitivity.
They are useful when safety questions concern contact with a substance over time rather than a single event. By applying a controlled exposure schedule and monitoring health indicators, investigators can characterize potential toxicity and identify effects relevant to longer-term contact. The resulting evidence can support risk characterization and the development of exposure limits for environmental or occupational settings.