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Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)
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Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Article DOI: 10.3791/3936-v • 12:36 min • March 17th, 2012
March 17th, 2012 •
1, 1, 1, 1,2, 1,2, 1
1Dept. of Neurology, University Medicine Göttingen, 2DFG Research Center for the Molecular Physiology of the Brain (CMPB), Göttingen, Germany

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A mouse model for amyotrophic lateral sclerosis (ALS) is examined clinically and behaviorally. As a prerequisite for an accompanying immunohistological analysis the preparation of the spinal cord is depicted in detail.

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Clinical Testing Spinal Cord Removal Mouse Model Amyotrophic Lateral Sclerosis ALS Neurodegenerative Disorder Motoneurons Familial Mutations SOD Gene SOD1 (G93A) Mutation Overall Survival Clinical Course Motor Function Behavioural Motor Tests Quantitative Scoring Systems Immunohistochemical Examination Spinal Cord Preparation Dorsal Laminectomy Method Histological Findings Therapeutic Options Human Clinical Trials
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