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Journal / Biochemistry / Metode for å identifisere lavmolekylære…
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Biochemistry

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JoVE Journal Biochemistry
Metode for å identifisere lavmolekylære inhibitorer av protein-protein samhandling mellom HCN1 og TRIP8b
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Metode for å identifisere lavmolekylære inhibitorer av protein-protein samhandling mellom HCN1 og TRIP8b

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

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Samspillet mellom HCN kanaler og deres hjelpe subenheten har blitt identifisert som et terapeutisk mål i Major Depressive Disorder. Her, en fluorescens-polarisasjons-basert metode for identifisering av lavmolekylære inhibitorer av dette protein-protein interaksjon, er presentert.

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Biokjemi High-throughput screening medisiner protein-protein interaksjoner fluorescens polarisering HCN TRIP8b
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