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A Murine Model of Hemodialysis Access-Related Hand Dysfunction

Article DOI: 10.3791/63892-v • 08:39 min • May 31st, 2022
May 31st, 2022 •
1, 2,4, 2,4, 2,4, 2,4, 1,3, 2,4
1Department of Applied Physiology and Kinesiology, University of Florida, 2Division of Vascular Surgery and Endovascular Therapy, University of Florida, 3Center for Exercise Science, University of Florida, 4Malcom Randall Veteran Affairs Medical Center

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This protocol details the surgical steps of murine common iliac arteriovenous fistula creation. We developed this model to study hemodialysis access-related limb pathophysiology.

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Murine Model Hemodialysis Access-related Hand Dysfunction Animal Model Mechanisms Dialysis Access-related Hand Ischemia Uremia Neuromuscular Perturbations Hemodynamic Changes Arterial Venous Fistula Surgery Patient Quality Of Life Disability Novel Therapies Procedure Anesthetized Mouse Supine Position Surgery Table Sterile Drape Ocular Lubricant Pen Trimmer Abdominal Hair Leg Hair Postoperative Perfusion Measurements Upper Extremities Lower Extremities Rubber Bands Tacks Depth Of Anesthesia Toe Pinch Reflex Respiratory Pattern Evaluation Midline Laparotomy
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