Brain Metabolism
Brain Metabolism - Related Videos
10:21
Metabolic Support of Excised, Living Brain Tissues During Magnetic Resonance Microscopy Acquisition
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Cited by 2 •
2017
The current protocol describes a method by which users can maintain viability of acute hippocampal and cortical slice preparations during the collection of magnetic resonance microscopy data.
06:50
Advancements in the Metabolic Profiling of Three-Dimensional Brain Tumor Spheroids for Drug Screening
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Cited by 1 •
2025
Here, we establish a metabolic profiling platform integrating three-dimensional (3D) glioma spheroids and imaging-based normalization via extracellular flux analysis. This approach enables more accurate assessment of tumor metabolic responses to drug treatments and provides insights into potential mechanisms of resistance.
03:47
Assessing Metabolic Neuromodulation Induced by Acute Deep Brain Stimulation in Rats Using In Vivo FDG-PET
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2025
Source: Casquero-Veiga, M. et al. In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats. J. Vis. Exp. (2022).This video demonstrates the metabolic effects of deep brain stimulation (DBS) using FDG-PET imaging in a rat model. It outlines the steps involved in FDG administration, DBS application, and PET/CT imaging to map brain regions with increased or suppressed metabolic activity.
05:41
Metabolic Profile Analysis of Zebrafish Embryos
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Cited by 42 •
2013
Zebrafish represent a powerful vertebrate model that has been under-utilised for metabolic studies. Here we describe a rapid way to measure the in vivo metabolic profile of developing zebrafish that allows the comparison of different mitochondrial function parameters between genetically or pharmacologically manipulated embryos, thereby increasing the applicability of this organism.
00:52
What is Metabolism?
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2019
Overview Metabolism represents all of the chemical activity in a cell, including reactions that build molecules (anabolism) and those that break molecules down (catabolism). Anabolic reactions require energy, whereas catabolic reactions provide it. Thus, metabolism describes how cells transform energy through a variety of chemical reactions, which are often made more efficient with the help of enzymes. Metabolism Is the Sum of All of the Chemical Reactions That Take Place in an Organism
FAQs
Brain Metabolism channels glucose through glycolysis and then mitochondrial oxidative phosphorylation. Glycolysis begins processing the nutrient, while mitochondria carry out the oxygen-dependent stage that produces ATP, the cell’s usable energy currency. Considering both stages helps researchers relate nutrient use and oxygen consumption to the energy available for neural cells.
In Brain Metabolism, oxygen use and blood flow help align energy delivery with neural activity. When activity changes, these variables provide information about whether the supply supporting neural cells is changing in parallel. This relationship matters because metabolic measurements can reflect not only biochemical energy production but also the delivery conditions that sustain it.
Neurons and glial cells both take up nutrients, so analyses of Brain Metabolism should account for more than neuronal activity alone. Their shared participation links cellular nutrient handling to maintenance of brain structure and function. This perspective is useful when interpreting metabolic changes, because an observed shift may reflect altered energy demands across neural cell populations.
Researchers use metabolic measurements and imaging to examine how energy-related processes change in the brain. These approaches can connect biochemical activity with patterns associated with development, cognition, disease, or injury. The resulting observations help investigators ask whether altered metabolism accompanies changes in neural function, rather than treating energy production as separate from brain activity.
Development, cognition, disease, and injury all provide important contexts for examining metabolic change. Comparing these contexts can show whether energy-related patterns vary with normal brain maturation, mental activity, or pathology. This broad relevance makes metabolism a bridge between cellular biochemistry and brain function, supporting research that connects biochemical processes with changes in the brain.
Altered energy production can provide a mechanistic clue when neural function is impaired. In stroke and neurodegeneration research, investigators examine whether disrupted energy production is associated with functional changes. Similar analysis in injury studies can connect biochemical disturbances with brain performance, while metabolic measurements and imaging provide ways to track that relationship.